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Signal Transduct Target Ther 9(1):17 Tariot PN, Cummings JL, Katz IR, Mintzer J, Perdomo CA, Schwam EM, Whalen E (2001) A randomized, double-blind, placebo-controlled study of the efficacy and safety of donepezil in patients with Alzheimers disease in the nursing home setting

Given intraneuronal Zn concentrations are controlled with femtomolar sensitivity, [42] it is likely that Zn is chaperoned to SOD1 rather than acquiring it from a labile diffusible pool