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10 Historically, even though inpatients are generally monitored daily, for outpatient therapy, the INR is monitored once or twice weekly until the warfarin dose is determined and INR stability is achieved

Acidic pH impairs the activity of the mitochondrial L-2-HG removal enzyme L-2-hydroxyglutarate dehydrogenase (L2HGDH) and enhances the protein stabilization of HIF-1, leading to its escape from the degradation pathway 90

However, this is not a systematic review

Most commonly via subcutaneous injection near the injury site or systemically