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But for the right patient, it may restore the biological foundation that every other intervention depends on

Firstly, the field must advance standardized life-cycle exposure models that track ENMs from synthesis through environmental release, transformation, and biological uptakean area having significant research gap (e.g., bioaccumulation of transformation products) (Pietroiusti et al., 2016)

10.20471/acc.2020.59.01.03 [DOI] [PMC free article] [PubMed] [Google Scholar] 58.iberna L, Jenko-Pranikar Z, Petelin A

These include ferroptosis suppressor protein 1(FSP1)/CoQ10, GTP cyclohydrolase1 (GCH1)/tetrahydrobiopterin (BH4), and dihydroorotate dehydrogenase (DHODH) ( Figure 1 )