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Enzymatic reactions, such as those involving cytochrome P450, xanthine oxidase, and nitric oxide synthase, can also produce free radicals [14]

Acknowledgments This research was performed using equipment from the Core Centrum Genomic Technologies, Proteomics and Cell Biology in ARRIAM

However, WES enables the comprehensive analysis of approximate ~19,500 protein-coding genes and, depending on the library (e.g., Agilent SureSelect CRE V4), approximately 5,500 additional clinically relevant loci, including splice sites, untranslated regions, lncRNAs, pseudogenes, and regulatory elements

Future research needs to focus on elucidating the precise mechanisms of flavonoids, optimizing their pharmacokinetic properties, and conducting more standardized clinical trials to facilitate the transformation of these natural compounds into standardized immunomodulatory therapeutic agents

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