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World J Gastroenterol 19:7374

Nevertheless, not all the trials possessed the essential prerequisites to confirm the true potential of this approach

evidence for systemic effects via oral route in humans is absent as of this writing

The stakes are simply too high.

Abbreviations ALT: Alanine aminotransferase ALP: Alkaline phosphatase AST: Aspartate aminotransferase CCSEA: Committee for Control and Supervision of Experiments on Animals CP: Cyclophosphamide ELISA: Enzyme-linked immunosorbent assay FF: Fenofibrate GGT: Gamma-glutamyl transferase GSH: Reduced glutathione H&E: Hematoxylin and eosin H 2 O 2 : Hydrogen peroxide IHC: Immunohistochemistry IL-1: Interleukin-1 IL-6: Interleukin-6 LEV: Levocabastine MDA: Malondialdehyde MT: Massons trichrome NO: Nitric oxide Nrf2: Nuclear factor erythroid 2-related factor NF-B: Nuclear factor kappa-B OH: Hydroxyl radical ROS: Reactive oxygen species SD: Standard deviation SOD: Superoxide dismutase TBARS: Thiobarbituric acid reactive substance TGF-: Transforming growth factor-beta TNF-: Tumour necrosis factor-alpha References Abdel-Wahhab KG, Mannaa FA, Ashry M, Khaled DM, Hassan LK, Gomaa HF (2021) Chenopodium quinoa ethanolic extract ameliorates cyclophosphamide -induced hepatotoxicity in male rats