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This is particularly important for individuals with conditions that interfere with B12 absorption, such as pernicious anemia, gastrointestinal disorders like celiac disease or Crohns disease, or those who have undergone certain types of gastrointestinal surgery

[7] To minimize such effects, clinics now administer NAD+ infusions slowly (over several hours) or use divided subcutaneous doses

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On the other hand, they can cause cardiac hypertrophy, tachycardia, muscle catabolism, and bone deterioration

Finally, glycemic variability, particularly when associated with hyperglycemia, occasions significant damage to barrier integrity, affects essential nutrient transport functions, and generates significant oxidative stress in the central nervous systems blood capillaries, all factors that must be managed during concussion rehabilitation