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For example, GABAergic interneurons (e.g., parvalbumin-positive neurons) possess different redox dynamics and delayed antioxidant system maturation, making them particularly vulnerable to oxidative stress during critical developmental windows [94, 95]

InagiR.Glycative stress and glyoxalase in kidney disease and aging

The mechanism relies on glutathione as a cofactor, and disruptions in its availability can sensitize cells to ferroptosis

Effect of concomitant use of pentoxifylline and alpha-tocopherol with radiotherapy on the clinical outcome of patients with stage IIIB non-small cell lung cancer: a randomized prospective clinical trial

Considering the positive impact of Nrf2 in ameliorating oxidative stress, a number of bioactive components that exert protective effect against APAP-associated hepatotoxicity have been identified and reported, including caffeic acid that activates the Keap1-Nrf2 antioxidant defense system (Pang et al., 2016), carnosic acid that promotes nuclear translocation of Nrf2 (Guo et al., 2016), and esculentoside A that activates Nrf2 via AMP-activated kinase/Akt/glycogen synthase kinase 3 pathway (Wang et al., 2016)