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In summary, our discovery of the isoxazole Acs inhibitors and the structural and biochemical characterization of their mechanism of inhibition provides novel insights that should be useful to the design of Acs inhibitors for both infectious disease indications as well as the treatment of human cancers and metabolic diseases

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p16 is crucial for maintaining senescence by regulating Rb protein phosphorylation to inhibit cell division 9

PubMed Alba, M., Fintini, D., Bowers, C.Y., & Salvatori, R