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Its Innovative Science and Technology Approaches for New Drugs (ISTAND) pilot program is explicitly considering complex in vitro models like OoCs, with a liver-on-chip for DILI being the first OoC accepted into the program for evaluation (222)

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Therapeutic modulation through targeted probiotics or precision nutrition emerges as a promising strategy to restore microbial equilibrium, with clinical studies suggesting concomitant improvements in both immunological parameters and quality-of-life metrics (Liao et al., 2022

Where exactly is the patient centred, solid, qualitative, peer-reviewed research from back when this ridiculously illogical idea originated