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Congruent with our result, Regland et al

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People who should be vaccinated: Pneumococcal vaccine is recommended for people aged 65 and over, people with chronic heart, lung, liver, kidney disease, diabetes, splenectomy, hypersplenism cases, regardless of age group, HIV-infected patients, those who have undergone solid organ and hematopoietic stem cell transplantation, and those who have been using immunosuppressive drugs such as corticosteroids for a long time

In diabetic cardiomyopathy (DCM), a range of pathological processes occurs, including increased oxidative stress, mitochondrial dysfunction, impaired cardiac insulin signaling, reduced nitric oxide (NO) bioavailability, impaired calcium handling in both mitochondria and cardiomyocytes, cardiac autonomic neuropathy, activation of the renin-angiotensin-aldosterone system, inflammation, and microvascular dysfunction [25]