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In vitro perfusion studies, using isolated proximal convoluted tubules and in vitro studies using OK cells, showed that IGF-1 directly increases phosphate reabsorption via increase of protein levels of Na-Pi2a at the plasma membrane, which could be completely blocked by an anti-IGF-1R antibody [5153]

In biological systems, they function as signaling molecules: the body uses them to tell specific cells to do specific things

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How Do These Peptides Impact Memory and Cognitive Function

Morphine also produces venodilation , which can also reduce venous return & preload (oxygen demand)