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The phosphorylated tyrosine residues on the receptor create docking sites for many adapter proteins and signaling molecules, most notably insulin receptor substrate proteins (IRS-1 and IRS-2)

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Some patients may experience minimal benefit or no benefit from peptide therapy

Depending upon the nature of the polypeptides (i.e., percent hydrophobicity, percent hydrophilicity, stability, net charge, isoelectric point etc.), it may be useful to conjugate the immunizing agent to a protein known to be immunogenic in the mammal being immunized