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Introduction -thalassemia is the most common inherited disease, characterized by decreased or absent -globin chain synthesis and hemoglobin A production ( The incidence of myocardial iron overload in transfusion-dependent -thalassemia patients has increased from 11.4%15.1% in early studies to 26.1%36.7% in recent studies ( As iron loading progresses, the capacity of transferrin to bind and detoxify iron is eventually exceeded, leading to non-transferrin-bound iron in plasma, which promotes oxidative stress, mitochondrial dysfunction, and ferroptosis ( Mechanisms of myocardial injury caused by iron overload Studies have shown that iron myocardial overload causes myocardial dysfunction

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However, baclofen may be considered in cases where: Standard acid-suppressing medications do not fully control symptoms

Geber W, Lefkowitz S, Hung C, Effect of ascorbic acid, sodium salicylate, and caffeine on the serum interferon level in response to viral infection Pharmacology 1975 13(3):228-233