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One consideration for determining whether the billing activity has national or regional significance would be if the pattern warrants an adjustment to or special assumption for calculating official Medicare expenditure trends (such as the United States Per Capita Cost (USPCC) or Federal budget forecasts) due to the activity's significant, anomalous, and highly suspect nature

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That extra step can prevent confusion between micrograms, milliliters, and total vial contents

Vitamin B 12 supplements are available as single or multivitamin tablets

For these reasons, CMS proposed to establish an estimation methodology to remove 340B units from the total number of units for a Part D rebatable drug, as described in this section