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Defects in RNA processing steps contribute to a variety of human diseases ranging from motor neuron diseases to cancer

Cardiac-specific elision of Fth1 (encoding ferritin heavy chain) causes iron dysregulation and increased oxidative stress in the heart, leading to increased sensitivity to ferroptosis induced by iron overload [76]

Mitochondria were treated with pyruvate/malate/FCCP followed sequentially with rotenone, succinate, antimycin A, and N,N,N,N-Tetramethyl-p-phenylenediamine (TMPD)/ascorbic acid (n = 5)