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Yang et al (283), discovered that the dual-targeting of IL-6, which stimulates different macrophages activation in GBM, and CD40 may help in reversing tumor immunosuppression mediated by macrophages thus informing the immunotherapy based on T-cells against GBM

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however, since activation of both CCR2 and CCR5 receptors directly activate hepatic stellate cells which promote hepatic fibrosis (433), further investigation on the effects of cenicreviroc on vSMCs are indicated to determine whether treatment affects atherosclerotic plaque stability

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10.1016/j.cell.2013.12.010 109 YuY.JiangL.WangH.ShenZ.ChengQ.ZhangP.et al (2020)

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