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In addition, microbial overgrowth impaired the uptake and metabolism of PUFAs and other molecules

Both RFK and FLAD1 reside in the cytosol and within mitochondria, allowing newly formed FAD to accumulate in the mitochondrial matrix, where it serves as an essential co-factor for numerous flavoproteinsincluding ETF-DH, AIFM1, multiple acyl-CoA dehydrogenases, and glutathione reductase (Figure 1) (60)

10.1016/j.cbi.2019.06.036 84 LuoZ.WangY.XueM.XiaF.ZhuL.LiY.et al (2021c)

Conformational analysis of broken rodlike chains

However, because it stimulates three metabolic pathways instead of one or two, some patients may experience more pronounced side effects, including nausea, diarrhea, or fatigue