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J Clin Invest 121:36353644 Negro R, Gobessi S, Longo PG, He Y, Zhang ZY, Laurenti L, Efremov DG (2012) Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT

The relationship runs both ways

The exact cause of IBD is not yet fully understood, although it is considered to occur due to a complex interplay between genetic, environmental and immune system factors