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The second most common metastatic site of breast cancer is the brain (73)

Methods: MiR-126 mimics and inhibitors were transfected into M1 polarization macrophages RAW264.7 induced by LPS in vitro,Mertk and ADAM9 were detected by western blotting,inflammatory and anti-inflammatory cytokines were tested by qPCR.Apoptotic AML12 cells were added and co-cultured with the transfected macrophages,apoptosis related proteins were detected by Western Blotting,efferocytosis/phagocytosis index were observed by fluorescence microscope.Finally,miR-126 loaded into the exosomes of mesenchymal stem cells co-cultured with M1 polarization macrophages,efferocytosis index and the expression of related signaling pathway proteins were detected

2017 Apr 27;10:147-153.

Evaluation of energy and glucose homeostasis The body weight of AgRP GHR KO, LepR GHR KO and brain GHR KO mice, as well as of their respective control animals, was monitored weekly

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