glutathione attaches to What is Glutathione? – GoldBio Mode of action of Glutathione

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While the greater amount of cellular reduced GSH is found in the cytosol and mitochondria, the endoplasmic reticulum becomes a reservoir of small concentrations of the oxidized form of GSH (GSSG)

Chinese Journal of Natural Medicines , 12 ( 6 ), 401406

The elevated pro-oxidant production not only increases the net amount of pro-oxidants in the hepatocyte, but also directly damages mitochondrial proteins and DNA, which can aggravate mitochondrial aging and activate apoptotic pathways [113]

Moreover, through PPAR activation, both cannabinoids inhibit NF-B-mediated inflammation and enhance Nrf2-coordinated antioxidant responses