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TABLE 1 Overview of the small molecule inhibitors targeting NNMT

Inositol is best when combined with choline to increase fat burning activity

The SURMOUNT data shows continuous weight loss through week 40 on average, with slowing but not stopping through week 72

A separate category, including CJC-1295 and Sermorelin, works through growth-hormone stimulation instead of appetite signaling: these peptides prompt the pituitary gland to release more of the body's own growth hormone, which supports fat metabolism and helps preserve lean muscle during a calorie deficit

Tesofensine offers a compelling tool for athletes, competitors, and serious dieters who struggle with hunger, adherence, or energy during cutting phases