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Activated Protein C (aPC) in turn leads to the inactivation of the prothrombinase complex (= FXa + FVa) at sites with an intact endothelium (Figure 1

It has therefore been proposed that future treatment of gastric motor dysfunctions and related symptoms should be based on identified pathophysiology or actionable biomarkers that is putative mechanisms that are associated with induction of the symptoms suggesting gastroparesis and that can be normalized with specific treatments, such as treatments targeting5-HT 4 , dopamine D 2 and D 3 , and NK 1 receptors

The treatment of PDAC requires novel targets and increasing interest in research regarding novel cancer biomarkers has been focused on the GST family which contributes to the malignant phenotype of many cancers

Gut inflammation and barrier dysfunction may facilitate -synuclein misfolding in the enteric nervous system, with retrograde propagation via the vagus nerve (Li et al., 2023

Sattar N, McConnachie A, Shaper AG, Blauw GJ, Buckley BM, de Craen AJ, Ford I, Forouhi NG, Freeman DJ, Jukema JW, Lennon L, Macfarlane PW, Murphy MB, Packard CJ, Stott DJ, Westendorp RG, Whincup PH, Shepherd J, Wannamethee SG