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1, 451459.10.1016/j.actbio.2005.04.004 98 MontesanoR.KumarS.OrciL.PepperM

CFTR has physiological functions as a chloride and bicarbonate channel and a role in regulating water movement

however, it also induces tissue damage due to the excessive immune responses (233)

Gene expression studies using microarray analysis reported that GHK-Cu at low nanomolar concentrations influenced the expression of over 4,000 human genes in fibroblast models, including upregulation of collagen I, collagen III, and elastin synthesis, and modulation of matrix metalloproteinase activity (Pickart and Margolina, Symmetry 2018)