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R PAPS is synthesized in two steps: ATP sulfurylase condenses ATP and inorganic sulfate to form adenosine-5'-phosphosulfate (APS), then APS kinase phosphorylates APS to form PAPS (at the cost of a second ATP)

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Furthermore, genome-wide CRISPR screening identified SEC24 homolog B (SEC24B) as a key regulator of ferroptosis, and its knockout significantly inhibited ferroptosis in microglia (Ryan et al., 2023b)

HGF and SCF treatment reduced ROS levels, preserved mitochondrial membrane potential, and upregulated mitochondrial-related protein expression in hBM-MSCs