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Moreover, adenosine builds up while awake, but extracellular adenosine concentration does not increase during SD, indicating that adenosine regulation during sleep and wakefulness is complex and that SD might also have a direct impact on adenosine tone (Zeitzer et al., 2006

References Chidambaran V, McAuliffe JJ

It is one potentially modifiable biochemical burden that may coexist with methylation imbalance, oxidative stress, copper-zinc dysregulation, pyroluria, gut dysfunction or immune activation

In V1.1, clearances were calculated from the measured 13C-CA and d4-CA concentrations

Methods OCTN2 protein expression and purification Full-length human wild-type OCTN2 (Uniprot accession: O76082) was synthesized and cloned into the pcDNA3.1 vector by Genscript