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139,140,141 Although dual agonists show advantages in efficacy, their safety and tolerability continue to be a focus of ongoing monitoring

Moreover, behavioral disinhibition has been reported in the APP SAA knock-in model (Xia et al., 2022)

Research and Capacity Investment: Strengthen laboratory capacity, develop child-specific exposure models, and evaluate intervention effectiveness

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Research models with chronic metabolic dysfunction often show NNMT overexpression that outpaces NAD+ synthesis capacity, creating a ceiling on how much metabolic improvement MOTS-c alone can produce