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Fluctuations in hormone levels during pregnancy or menopause could trigger an increase in melanin production, leading to the appearance of these dark spots on the lips

doi: 10.3390/ijms21239182 35 Obi-NagataKTemmaYHayashi-TakagiA

J Ethnopharmacol 136(2):355362 Francisco V, Costa G, Figueirinha A, Marques C, Pereira P, Miguel Neves B, Celeste Lopes M, Garca-Rodrguez C, Teresa Cruz M, Teresa Batista M (2013) Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-B pathway inhibition: contribution of chlorogenic acid