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These proteins, known as flippases or FIC1, are involved in maintaining an asymmetric distribution of phospholipids across the canalicular membrane of hepatocytes, thereby protecting the canalicular membrane from hydrophobic BAs and maintaining its integrity

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Studies & further reading If you want to go to the primary sources, here are the most authoritative references behind this article peer-reviewed studies, regulatory bodies, and university science communicators

Stem Cell Res 10(1):117 Waltenberger J (2007) New horizons in diabetes therapy: the angiogenesis paradox in diabetes: description of the problem and presentation of a unifying hypothesis