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The upregulation of HO-1 increases the LC3-II/I ratio, decreases mTOR expression, and leads to excessive autophagy, exacerbating ferroptosis in PM2.5-exposed hippocampal neurons

Glaucomatous outflow pathway and oxidative stress

It plays a central role in several vital functions

For the AD model, we used a previously described animal model of focal DTR (diphtheria receptor)-expressing astrocytes in APP/PS1 mice (fGiD)