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Produced by the liver in response to GH, it activates the IGF-1R receptor in muscle cells, triggering the PI3K/Akt/mTOR pathway, which stimulates protein synthesis, inhibits proteolysis, and promotes the proliferation of satellite cells (muscle precursors)

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Subjective improvement in pain, function, and activity tolerance provides the primary effectiveness signal

Dysbiosis-driven CNTF upregulation may trigger aberrant synaptic pruning by microglia within the CA1 subregion of the hippocampus

Collectively, these findings advocate for a personalised, clinically guided approach to probiotic supplementation