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Plasma and pericardial fluid preparation for NMR analysis Plasma samples were prepared in accordance with standard protocols for NMR metabolomics investigations 36

Ferroptosis-associated oxidative stress also influences post-translational modifications of ATG proteins, fine-tuning their activity and localization (63-65)

These interventions should be individualized and biomarker-guided (e.g., endothelial function, Prx redox state, GSH/GSSG, F 2 -isoprostanes, LIP assays) and titrated to preserve beneficial H 2 O 2 -based signalling while preventing convergence onto ONOO , hydroxyl-radical formation and runaway lipid peroxidation (Frijhoff et al

Abbreviations A-DecNef: Associative decoded fMRI neurofeedback ADHD: Attention-deficit/hyperactivity disorder APA: American Psychological Association ASD: Autism spectrum disorder DSM: Diagnostic and statistical manual of mental disorders EEG: Electroencephalography ECG: Electrocardiography fMRI: Functional magnetic resonance imaging HCP: Healthcare provider IQ: Intelligence quotient MED: Methylphenidate MRI: Magnetic resonance imaging NF: Neurofeedback RCT: Randomised controlled trial References Barbaresi WJ, Colligan RC, Weaver AL, Voigt RG, Killian JM, Katusic SK

Works to neutralize free radicals in the body causing oxidative stress to the cellular structure