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Targets 5 , 477489 (2001)

Accordingly, we hypothesized that these interventions would attenuate mucositis through improvements in redox balance and inflammatory status, and the study objectives were formulated to evaluate these effects and clarify their potential links to Nrf2 signaling

Modulation of sensitivity to phospholipid oxidation and ferroptosis by tumor suppressors and oncogenes is mediated by changed expression or activities of proteins that exert different functions in lipid peroxidation including those regulating iron handling (transferrin receptor, NCOA4), enzymes synthesizing peroxidation-prone PUFA-phospholipids (ACSL4), antioxidant enzymes (GPX4) and proteins involved in production of antioxidant proteins (NRF2) or small antioxidant molecules (SLC7A11, FSP1)

Autoimmune thyroid conditions generally take years to develop, so effective and lasting treatments are generally not quick-fixes