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For example, epidermal growth factor (EGFs), angiopoietins (ANGs), hepatocyte growth factor (HGF), fibroblast growth factors (FGFs), transforming growth factors (TGFs), stromal cell-derived factor 1 (SDF1) and placental growth factor (PlGF) are potent inducers of angiogenesis that are upregulated upon anti-VEGF treatment [205]

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This suggests that during nutrient deprivation, the consumption of extracellular alanine by cancer cells negatively impacts T cell function