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The Neelakantan 2018 study in Biochemical Pharmacology reported that 5-Amino-1MQ administration to C57BL/6 mice on a 60% kcal-from-fat high-fat diet produced concentration-dependent reductions in fat mass and adipose-tissue NNMT enzymatic activity without significant changes in lean mass or food intake [1]

First, side effects are clearly dose-dependent, increasing as the dose goes up

A lack of vitamin B12 - caused e.g

Those with Cognitive Concerns: B12 is essential for brain health, and supplementation may support cognitive function

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