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If someone doesnt make enough of it, or if what they do make doesnt work that well, theyre unable to sufficiently regenerate that antioxidant in their RBCs, so events that trigger a lot of ROS (such as getting severe infections, eating raw fava beans, or taking certain drugs) can cause so much oxidative stress and damage to the cells lipid membranes that those RBCs explode and/or get degraded, leading to a phenomenon called hemolytic anemia