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Thalidomide has been reported to increase hemoglobin levels or decrease blood transfusion volume by 50% in 78% of children with -thalassemia and partial or declining response to hydroxyurea ( Anti-oxidants treatment Recent research indicates that antioxidant treatment might exert a key role in controlling this situation by alleviating the oxidative stress related to iron overload

However, their clinical application faced challenges related to variable bioavailability, individual pharmacokinetics, optimal dosing, and limited clinical evidence

This work was funded by the Mikkeli University Consortium (MUC) with the project number 23B350E6YT10

Distribution of recombinant interferon- 2 administered subcutaneously with oedematogenic drugs