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GLS-2 is considered more of a tumor suppressor than GLS-1

doi: 10.1016/j.jtemb.2014.12.007

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Hepatocyte hyperproliferation upon liver-specific co-disruption of thioredoxin-1, thioredoxin reductase-1, and glutathione reductase

However, these inconsistencies may be due to variations in disease chronicity, age, and symptom severity among study participants