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A study on average brain concentrations after 6 doses found an average brain concentration of 0.54 lg/g brain tissue, corresponding to an average brain tissue concentration of 3 lM (Smeyne et al., 2016)

5,6 This self-damaging chain reaction of Hb leads to the formation of ferryl hemoglobin (Fe 4+ =O), globin radicals, and reactive oxygen species (ROS), which further contribute to oxidative damage

With the addition of supplemental L-Carnitine, the muscles are getting both an increased natural supply and more through supplementation

Following oxidative insult, the activity of the oxidative branch increases to direct the non-oxidative branch toward resynthesizing F6P, which is then converted back to G6P to replenish the oxidative branch, allowing enhances for NADPH generation

This coordinated activation of three complementary pathways explains the unprecedented 24.2% average weight loss observed in Phase 2 trials