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Additionally, the applicant stated that VANFLYTA, if approved, would be the only AML drug indicated for continuation monotherapy following consolidation chemotherapy (for up to 3 years), based on showing activity as a single agent for that use, and that therefore, the technology meets the newness criterion

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(2023) 7:e2300293

First, because Munc13-4 is mainly expressed in immune cells, ENDO-mediated inhibition of eTLRs and inflammation is more targeted than, for example, CQ derivatives

RNA-Seq libraries were prepared from 200 ng of total RNA with the Illumina TruSeq Stranded mRNA reagents (Illumina) using a unique dual indexing strategy and following the official protocol automated on a Sciclone liquid handling robot (PerkinElmer)