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Paradoxically, elevated ROS levels and cardiac dysfunction were also observed in DN-NOX4 mice under IR challenge, indicating that high NADPH and GSH levels also enhance ROS generation and induce reductive stress by mechanisms yet to be determined (116)

Author Contributions Concept and design: Amer Yahia, Zoubaida Yahia, Tarek Abdelaziz Acquisition, analysis, or interpretation of data: Amer Yahia, Zoubaida Yahia, Tarek Abdelaziz Drafting of the manuscript: Amer Yahia, Zoubaida Yahia, Tarek Abdelaziz Critical review of the manuscript for important intellectual content: Amer Yahia, Zoubaida Yahia, Tarek Abdelaziz Supervision: Amer Yahia, Zoubaida Yahia, Tarek Abdelaziz References 1.Clinical evaluation of a new mucolytic agent, acetyl-cysteine