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76 ZhangX.LevyD.KainzV.NosedaR.JakubowskiM.BursteinR

Autoimmune diseases and atherosclerotic cardiovascular disease

It is the silent reserve, always present

During AD, an uncoupling between the insulin receptor (IR) and the insulin receptor substrate 1 (IRS1) occurs as a consequence of the downregulation of IR expression and/or the inactivation of IRS proteins leading to the inability of insulin to promote its normal cellular downstream outcomes