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Diminished expression of numerous amino acids, particularly branched-chain amino acids, has been documented in individuals with COPD, demonstrating significant differences between acute exacerbation and stable phases (37,38)

The first by using as template all the structure retrieved by pdb100 mode plus Tha1 crystal structure (AF_F222) and the second by using as template only the Tha1 crystal structure (AF_only_F222)