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Description

Picalm reduction exacerbates tau pathology in a murine tauopathy model

Desforges J-P, Sonne C, Dietz R, Levin M

In brief, DBD of Max was divided into two peptide segments, which were synthesized via SPPS with the incorporation of four Cys residues at positions i, i + 4 [Asp32, Ser36, and Arg81, Leu85], two of which carried orthogonal acetamidomethyl (Acm) protection

However, different SCFAs likely have different metabolic fates, with primarily acetate feeding DNL and propionate and butyrate feeding gluconeogenesis