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Cancer and drug-resistant tumors Resistance to commonly used alkylating agents or platinum chemotherapeutic drugs is often multifactorial, involving altered drug transport, biotransformation and enhanced detoxification capacity (Lu, 1999a)

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LRE mechanistically elevated antioxidant enzymes such as GPX-4, Prdx-5, HO-1, and SOD-2, which are essential for alleviating oxidative damage