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[DOI] [PubMed] [Google Scholar] 16.Ellis EM

Nrf2 responds to cellular stress, for example under oxidative or neuro-inflammatory conditions, which are common features of neurodegenerative diseases, by increasing expression of an array of antioxidant response element (ARE)-containing genes to counteract damage (Bruns et al., Drosophila (Castillo-Quan et al., 2017), and pheno-copies specific GSK3 inhibition (siRNA and SB216763, TDZD-8) in increasing Nrf2 nuclear translocation and activating transcription of Nrf2 target genes, HO-1 and NQ01, in rat and mouse brain (Rojo et al., 2008