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Pathways regulating ferroptosis in AD Kelch-like ECH-associated protein 1 (Keap1)/Nrf2)/antioxidant response element (ARE) pathway In cellular defense against oxidative stress, the Keap1/Nrf2/ARE signaling pathway regulates the expression of various proteins involved in detoxification and antioxidant defense, positioning it as a potential target for AD treatment (61)

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We previously reported that reduced levels of activated hepatocyte growth factor and the c-Met receptor tyrosine kinaseboth of which are vital for maintaining cellular redox balancecombined with increased expression of GJ proteins in hepsin-deficient mice