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In contrast, combining antioxidants with treatments that induce apoptosis through ROS-independent pathways may provide synergistic benefits and improve therapeutic outcomes

Abdallah DM, Ismael NR

Neuron 76, 511517

Repeated overdoses can also occur with self-harm intent (often termed staggered overdoses), and similarly carry an increased risk of hepatotoxicity when compared to acute self-harm overdoses *

Peer review Peer review information Nature Reviews Neurology thanks Hlio Teive, Ludger Schls and the other, anonymous, reviewer(s) for their contribution to the peer review of this work