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Description

Brief Funct Genomic Proteomic

343,345 PARP1-mediated post-translational modifications of PKM2, such as PARylation, enhance its nuclear localization and activity, 346 driving the expression of genes involved in PASMC proliferation, endothelial dysfunction, and inflammatory cytokine production, which are central to pulmonary vascular remodeling

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Simplified molecular-input line-entry system (SMILES) codes were obtained from the MSP file or from the PubChem Compound Identifier Exchange service ( and chemical similarity enrichment calculations were done using ChemRICH 52