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Received: 13 May 2025 Revised: 04 June 2025 Accepted: 23 June 2025 Published: 27 June 2025 2025 The authors

Chronically elevated cortisol: Promotes visceral fat accumulation specifically, the metabolically dangerous intra-abdominal fat Drives hepatic glucose output, raising fasting blood sugar Suppresses adiponectin, a hormone that improves insulin sensitivity Increases appetite for calorie-dense foods by elevating ghrelin relative to leptin Impairs thyroid hormone conversion from T4 to active T3 This is why metabolic syndrome so frequently co-presents with sleep disorders

Neuroprotection and Repair Alzheimers and dementia research: Dihexa was developed as a potential therapy for neurodegenerative diseases, aiming to restore connectivity lost in conditions like Alzheimers