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Metabolomics APAP-induced liver injury biomarkers summary It is well established that translation of metabolic biomarkers from animal studies to humans is challenging due to the species difference as well as the confounding factors in humans including diet, age, lifestyle, overall health, drugdrug interaction and others, all of which will influence the metabolome profile

The derivative compound, curcumin, showed interesting antioxidant and anti-inflammatory effects in the context of several diseases, counteracting the oxidative damage and by reducing the inflammatory mediators ( in vitro studies have also demonstrated an antioxidant role of L-carnitine ( in vivo conditions

Bulk-forming laxatives contain materials, such as cellulose and psyllium, that pass through the digestive tract without being digested

ER primarily regulates nuclear gene transcription, while ER localizes to mitochondrial membranes, modulating mitochondrial metabolism and cellular stress responses (56)